Fig. 6

Ferroptosis inhibitors protect MDA-MB-231 cells, but not MCF-7 cells to LNC-induced toxicity. Cytotoxicity was assessed by measuring ATP levels (a) and [³H]thymidine incorporation (b) of MCF-7 cells and MDA-MB-231 cells treated with varying concentrations of LNCs for 24 h in the presence or absence of liproxstatin-1 (Liprox, 1 μM) or deferiprone (DFP, 100 μM). The data are shown as percent of control for each cell line not treated with LNCs. The data are shown as percent of control for each cell line not treated with LNCs. The graphs show mean values ± SEM from three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.005 for comparison of cells treated with Liprox, and ^#p < 0.05; ^###p < 0.005 for comparison of cells treated with DFP