Table 1 Biomedical application of nanomaterials in promoting neovascularization

Bone engineering

Nano-HA

(1) In vitro study (2) In vivo glucocorticoid-induced bone defect model

[28]

In vitro study

[29, 33, 154, 155]

In vivo ectopic osteogenesis study

[18]

In vivo calvarial defect model

[20, 99]

Micro/Nano-structured surfaces of Cu_x-HA

(1) In vitro study (2) In vivo subcutaneously implant study

[34]

TCP nanolayers

In vitro study

[21]

Nanofibrin

In vitro study

[24]

GO

In vivo calvarial defect study

[22, 26]

In vivo ectopic osteogenesis study

[27]

PCL nanofibrous biomembranes

In vivo maxillary bone lesion model

[16]

Mesoporous bioactive glass nanoparticles

(1) In vitro study (2) In vivo ectopic osteogenesis study

[30]

Copper doped in electrospun bioactive glass nanofibers

In vitro study

[17]

Micro-nano bioactive glass particles

In vitro study

[31]

Mesoporous silica nanoparticles

In vitro study

[32]

Soft tissue wound healing

Gold nanoparticles

(1) In vitro study (2) In vivo wound model

[14, 38, 43, 44]

Nano-sized bioactive glass

(1) In vitro study (2) In vivo wound healing assay

[39]

Cerium oxide nanoparticle

(1) In vitro study (2) In vivo wound model

[42]

the PCL nano-composite membranes incorporated with Zn-doped hollow mesoporous silica nanospheres

(1) In vitro study (2) In vivo wound model exposed to Escherichia coli

[40]

PLLA electrospun fibrous membranes

(1) In vitro study (2) In vivo diabetic wound model

[35]

Cu₂S Nanoflowers

(1) In vitro study (2) In vivo diabetic wound model

[36]

CaCuSi₄O₁₀ nanoparticles coated on the surface of Poly (ε-caprolactone) and Poly (D, L-lactic acid) (PP) fibers

(1) In vivo diabetic wound model cancer surgery-caused wounds in tumor-bearing mice

[37]

Nerve tissue repair

rGO

In vivo spinal cord hemisection model

[48]

PLGA nanoparticles

In vivo spinal cord hemisection model

[45]

Ischemia reperfusion

GO

(1) In vitro study (2) In vivo myocardial infarction model

[49, 50]

Tetrahedral DNA nanostructures

In vitro study

[137]