Fig. 6

In vivo expression of RBDV or IgG1 Fc. The LPPC/RBDV-IgG1 Fc protein complexes, LPPC/IgG1 Fc plasmid/RBDV-IgG1 Fc protein complexes, LPPC/RBDV-IgG1 Fc plasmid/IgG1 Fc protein complexes, LPPC/RBDV-IgG1 Fc plasmid/RBDV-IgG1 Fc protein complexes and PBS were i.v. injected into mice. Mouse sera were collected at different times post-administration and analysed by ELISA. LPPC, which encapsulated with RBDV or IgG1 Fc, were all complexed by PEG. The data represent the mean ± SD (n = 3). Significant differences were evaluated by ANOVA with the Bonferroni test