Fig. 4

SP-AH nanoparticles targeted breast cancer cells in vivo. a In vivo fluorescence imaging of mice with SKBR3 or MDA xenograft breast tumors following tail vein i.v. injection of SP-AH nanoparticles. Control mice with SKBR3 xenograft was injected with PBS only. Ex-vivo images of the same tumors were also shown. The color scale indicates epifluorescence intensity. b Fluorescence images of tissue sections of tumors from PBS- or SP-AH-injected mice. Red fluorescent signal, SP-AH particles. Blue signal, Hoechst staining of nuclei. Scale bar: 50 µm