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Table 3 Pharmacokinetics results after administrations with various formulations (n = 3)

From: Oral delivery of exenatide-loaded hybrid zein nanoparticles for stable blood glucose control and β-cell repair of type 2 diabetes mice

Formulation

Admin route

Dose (mg/kg)

Cmax (ng/mL)

Tmax (h)

AUC0–24 (ng h/mL)

BA (%)

Free EXE

s.c.

0.06

20.3

1

59.2 ± 10.9

100

DIS NPs

p.o.

0.6

2.19

8

33.2 ± 2.8

5.6 ± 0.5

COM NPs

p.o.

0.6

4.52

12

64.4 ± 15.2

10.9 ± 2.6*

  1. *P < 0.05 compared with the DIS NPs group
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Journal of Nanobiotechnology

ISSN: 1477-3155

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