Fig. 6
From: MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis
In vivo fluorescence imaging in normal or OA knees of mice. a Fluorescence imaging of OA joints injected with MRC-PPL, MRC-PPL + MMP-13 inhibitor, or MR-PPL at different time post-IA injection, as well as normal joint injected with MRC-PPL (excitation = 630 nm, emission = 700 nm). b The corresponding fluorescence intensity from OA joints at different times. c Ex vivo fluorescence imaging of heart, liver, spleen, lung, kidney, left knee and right knee at day 21 post-injection. (n = 5, mean ± S.D.)