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Table 3 Main pharmacokinetic parameters of drugs in rats after the intravenous injection of different drugs (n = 5)

From: Synergistic inhibition of metastatic breast cancer by dual-chemotherapy with excipient-free rhein/DOX nanodispersions

Drugs

Formulations

Cmax (μg/mL)

T1/2 (h)

AUC0-∞ (mg/mL·h)

CL (L/h/kg)

MRT0-∞ (h)

RHE

Free RHE

0.35 ± 0.10***

1.81 ± 0.57*

0.94 ± 0.52***

6.25 ± 2.65*

2.51 ± 0.98

RHE/DOX

0.62 ± 0.29***

2.15 ± 0.10*

1.25 ± 0.52***

4.49 ± 1.86*

2.59 ± 1.07

RD NPs

5.46 ± 0.92

6.87 ± 2.11

10.68 ± 1.04

0.47 ± 0.04

5.20 ± 2.31

DOX

Free DOX

0.36 ± 0.04*

2.92 ± 0.14*

1.59 ± 0.06*

3.15 ± 0.12***

5.07 ± 0.29*

RHE/DOX

0.52 ± 0.07

3.21 ± 0.05*

1.61 ± 0.15*

3.11 ± 0.30***

5.24 ± 0.60*

RD NPs

2.09 ± 0.48

7.14 ± 1.42

15.01 ± 5.55

0.37 ± 0.14

9.63 ± 2.33

  1. *p < 0.05, **p < 0.01, and ***p < 0.001 compared to RD NPs