Drugs | Formulations | Cmax (μg/mL) | T1/2 (h) | AUC0-∞ (mg/mL·h) | CL (L/h/kg) | MRT0-∞ (h) |
---|---|---|---|---|---|---|
RHE | Free RHE | 0.35 ± 0.10*** | 1.81 ± 0.57* | 0.94 ± 0.52*** | 6.25 ± 2.65* | 2.51 ± 0.98 |
RHE/DOX | 0.62 ± 0.29*** | 2.15 ± 0.10* | 1.25 ± 0.52*** | 4.49 ± 1.86* | 2.59 ± 1.07 | |
RD NPs | 5.46 ± 0.92 | 6.87 ± 2.11 | 10.68 ± 1.04 | 0.47 ± 0.04 | 5.20 ± 2.31 | |
DOX | Free DOX | 0.36 ± 0.04* | 2.92 ± 0.14* | 1.59 ± 0.06* | 3.15 ± 0.12*** | 5.07 ± 0.29* |
RHE/DOX | 0.52 ± 0.07 | 3.21 ± 0.05* | 1.61 ± 0.15* | 3.11 ± 0.30*** | 5.24 ± 0.60* | |
RD NPs | 2.09 ± 0.48 | 7.14 ± 1.42 | 15.01 ± 5.55 | 0.37 ± 0.14 | 9.63 ± 2.33 |