Fig. 4
From: Functionalized nanoparticles with targeted antibody to enhance imaging of breast cancer in vivo
MRI of tumors from mice injected with either G5-Gd-Trastuzumab or G5-Gd nanoparticles. Images were obtained prior to injection of contrast agents (base image) and at 1, 4, 24 and 48Â h post injection. The signal intensity in each image was normalized to the muscle tissue signal to account for signal variations due to animal position in the MRI probe. Imaging shows increased uptake of targeted particles that persisted for 48Â h