Fig. 4

Establishment of co-expression network centered with PD-L1 among Sr-exosomal differently expressed mRNA between twenty OS patients and six healthy donors. a Co-expression network centered with PD-L1 among the differently expressed genes; b KEGG analysis showing the cell adhesion co-expression with PD-L1, which was indicated by red arrow head; c Biological process including regulation of cell–cell adhesion and positive regulation of leukocyte cell–cell adhesion, which was also indicated by red arrow head; d–f Higher expression of exosomal N-cadherin and lower expression of exosomal E-cadherin in OS patients compared to healthy donors; g, h. Higher expression of exosomal N-cadherin in OS patients with metastasis compared to ones without metastasis