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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients

Fig. 4

Establishment of co-expression network centered with PD-L1 among Sr-exosomal differently expressed mRNA between twenty OS patients and six healthy donors. a Co-expression network centered with PD-L1 among the differently expressed genes; b KEGG analysis showing the cell adhesion co-expression with PD-L1, which was indicated by red arrow head; c Biological process including regulation of cell–cell adhesion and positive regulation of leukocyte cell–cell adhesion, which was also indicated by red arrow head; df Higher expression of exosomal N-cadherin and lower expression of exosomal E-cadherin in OS patients compared to healthy donors; g, h. Higher expression of exosomal N-cadherin in OS patients with metastasis compared to ones without metastasis

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