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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: The double-edged sword effect of macrophage targeting delivery system in different macrophage subsets related diseases

Fig. 1

DEX-PS uptake behavior by different macrophage subtypes. Mean fluorescence of whole cells (a) and Nile Red+ cells (b), and percentages of Nile Red+ cells (c) after incubation with various NPs. Representative confocal laser-scanning microscopy images of M1 (d) and M2 macrophages (e) incubated with PS, COOH-PS, or DEX-PS for 4 h. Kinetic profile of mean fluorescence of whole M1 (f) and M2 macrophages (g). Rate of DEX-PS uptake by M1 (h) and M2 macrophages (i) influenced by various inhibitors. j Fluorescence distribution of DEX-PS in MMR+ and MMR cells. Scale bars in d and e indicate 20 µm. Data are presented as the mean ± SD (n = 3), * Indicates p < 0.05. COOH-PS: carboxyl-functionalized polystyrene; DEX-PS: dextran-functionalized polystyrene; MMR: macrophage mannose receptor; PS: polystyrene

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