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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

Fig. 5

W20/XD4-SPIONs attenuated Aβ pathology in the brains of AD mice. a 6E10 immunostaining for plaques in the brains of AD mice treated with various SPIONs. Scale bars 400 μm. b Quantification of Aβ-immunostaining areas in (a). The levels of insoluble Aβ40 (c), insoluble Aβ42 (d), soluble Aβ42 (e) and soluble Aβ40 (f) in the brain lysates of AD mice and their WT littermates treated with various SPIONs were detected by ELISA. n = 8 mice/group. Data represent means ± SEM and were analyzed by one-way ANOVA with Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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