Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention

Table 1 Comparison of performance characteristics of different nebulizers

Parameters	Aerogen Solo	Omron NE C803	Pari LC	Sidestream^$
D_v(10) µm	5.89 ± 0.88	1.82 ± 0.07	1.89 ± 0.06	1.90 ± 0.04
D_v(50) µm	14.23 ± 1.21	4.37 ± 0.14	4.44 ± 0.19	4.20 ± 0.10
D_v(90) µm	31.31 ± 0.60	10.17 ± 0.39	10.03 ± 0.63	8.76 ± 0.17
GSD	1.91 ± 0.15	1.89 ± 0.06	1.83 ± 0.02	1.73 ± 0.04
Span	1.77 ± 0.18	1.95 ± 0.04	1.83 ± 0.05	1.63 ± 0.01
%V < 5 µm	7.17 ± 4.22	58.92 ± 1.75	56.85 ± 2.60	61.08 ± 1.40
%V < 1-3 µm	1.55 ± 1.07	30.40 ± 1.73	28.60 ± 1.69	29.67 ± 1.24

Dv(10): Microdrolpets below which 10% spray lies, Dv(50): Microdrolpets below which 50% spray lies, Dv(90): Microdrolpets below which 90% spray lies, GSD Geometric standard deviation; $: nebulizer finally selected for performance evaluation. Data expressed as mean ± SD (n = 3)

ISSN: 1477-3155