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Table 1 Comparison of performance characteristics of different nebulizers

From: Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention

Parameters Aerogen Solo Omron NE C803 Pari LC Sidestream$
Dv(10) µm 5.89 ± 0.88 1.82 ± 0.07 1.89 ± 0.06 1.90 ± 0.04
Dv(50) µm 14.23 ± 1.21 4.37 ± 0.14 4.44 ± 0.19 4.20 ± 0.10
Dv(90) µm 31.31 ± 0.60 10.17 ± 0.39 10.03 ± 0.63 8.76 ± 0.17
GSD 1.91 ± 0.15 1.89 ± 0.06 1.83 ± 0.02 1.73 ± 0.04
Span 1.77 ± 0.18 1.95 ± 0.04 1.83 ± 0.05 1.63 ± 0.01
%V < 5 µm 7.17 ± 4.22 58.92 ± 1.75 56.85 ± 2.60 61.08 ± 1.40
%V < 1-3 µm 1.55 ± 1.07 30.40 ± 1.73 28.60 ± 1.69 29.67 ± 1.24
  1. Dv(10): Microdrolpets below which 10% spray lies, Dv(50): Microdrolpets below which 50% spray lies, Dv(90): Microdrolpets below which 90% spray lies, GSD Geometric standard deviation; $: nebulizer finally selected for performance evaluation. Data expressed as mean ± SD (n = 3)