Fig. 6

Anti-lymphoma effect of CCM@MSNs-ISOIM in vitro was detected by flow cytometry and detection of apoptosis-related protein expression by WB. OCI-LY10 cells were treated with a) PBS, b) ISOIM, c) MSNs@ISOIM and d) CCM@MSNs-ISOIM for 48 h, respectively. A ROS level of OCI-LY10 cells was detected by flow cytometry after 48 h. B Flow cytometry was used to detect the apoptosis of OCI-LY10 cells after 48 h. C Flow cytometry was used to detect the changes of cell cycle of OCI-LY10 cells after 48 h. D Flow cytometry was used to detect the changes of MMP in OCI-LY10 cells after 48 h. E The expression of apoptosis-related proteins p53, Caspase-9 and Caspase-3 were detected by Western blotting. Data are presented as the mean ± SD (n = 3). (* p < 0.05, ** p < 0.01, and *** p < 0.001)