Table 3 Biological, engineering and clinical challenges in skin tissue engineering [167,168,169,170]
From: Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis
Biological Challenges | Engineering Challenges | Clinical Challenges |
|---|---|---|
Selection of a suitable cell source | Selection of biocompatible material | Adaptation of the scaffold to the surrounding tissue |
Repeatable cell differentiation condition | Optimal mechanical properties | Appropriate volume and shape of the regenerated tissue |
Selection of growth factors, biomolecules and bio-active agents | Repeatable scaffold fabrication condition | Post-surgical nutrition and oxygenation |