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Table 4 Pharmacokinetic parameters of TMP.HCl and TAT-TMP-NPs in plasma of SCI rats after intravenous injection (n = 5)

From: TAT-modified serum albumin nanoparticles for sustained-release of tetramethylpyrazine and improved targeting to spinal cord injury

Parameters

Unit

TMP.HCl

TAT-TMP-NPs

Mean ± SD

Mean ± SD

Cmax

µg/mL

150.957 ± 9.830

120.368 ± 7.118

Tmax

h

0.117 ± 0.067

2.200 ± 0.980

AUC0 − t

µg/mL * h

375.002 ± 33.859

1042.315 ± 44.987

MRT

h

2.418 ± 0.148

5.371 ± 0.038

t1/2

h

1.982 ± 0.259

8.329 ± 1.813

CL

mL/h/kg

22.000 ± 2.098

4.800 ± 0.748

Vd

mL/kg

63.600 ± 9.047

59.200 ± 6.615

  1. AUC0−t area under curve, MRT Mean residence time, t1/2 elimination half life time, CL total body clearance from plasma, Vd apparent volume of distribution
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Journal of Nanobiotechnology

ISSN: 1477-3155

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