Fig. 1

Identification and functional characterization of GI-associated miRNAs in BC patients. a Unsupervised clustering of 522 BC patients based on the expression pattern of 18 DEmiRNAs. The left purple cluster is GS-like group, and the right khaki cluster is GU-like group. Violin diagram of CSPM burden (b), UBQLN4 expression level (c) and aneuploidy scores (d) in the GU-like group and GS-like group. Horizontal lines: median values. Statistical analysis was performed using the Mann–Whitney U test. *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001. e, f. Functional enrichment analysis of KEGG and GO for target genes of miRNA. G. Kaplan–Meier estimates of overall survival of patients in the GU-like group and GS-like group. HRs and 95% CIs for high vs. low miGISig score was estimated using the univariate Cox analysis. P values comparing risk groups were calculated with the log-rank test. BC breast cancer, CIs confidence intervals, GI Genome instability, CSPM cumulative somatic point mutation, GO Gene Ontology, GS genomically stable, GU genomically unstable, HRs Hazard ratios, KEGG Kyoto Encyclopedia of Genes and Genomes