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Table 1 Comparison of blocking effect and CD47 reporter stimulation effect between B6H12 and HuNb1-IgG4

From: Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Ā 

B6H12

HuNb1-IgG4

Binding effect (EC50)

1.948Ā Ī¼g/mL

0.868Ā Ī¼g/mL

Blocking effect (IC50)

12.341Ā Ī¼g/mL

1.509Ā Ī¼g/mL

Affinity (KD)

7.81Eāˆ’09Ā M

4.85Eāˆ’09Ā M

  1. EC50 50% effective concentration, IC50 50% inhibitory concentration, KD equilibrium dissociation constant
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Journal of Nanobiotechnology

ISSN: 1477-3155

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