Fig. 3

Subcellular colocalization of fluorescence-labeled CaP nanoparticles (a, b) and CaP-MA-40 nanoparticles (c, d) with molecular probes of lysosome or caveosome in HEK239T cells observed by Laser Scanning Confocal Microscopy. The colocalization ratio of nanoparticles with lysosomes or caveosome (e). LysoTracker® Deep Red and CT-B were used as specific molecular probes to label lysosome and caveosome, respectively. *P < 0.05, colocalization ratio of CaP with lysosome compared with the counterpart in CaP-MA-40 group, ^#P < 0.05, colocalization rate of CaP with caveosome compared with the counterpart in CaP-MA-40 group