Fig. 18

I Schematic illustration of (A) the preparation process of PCN-224-Pt and (B) the use of PCN-224-Pt for enhanced photodynamic therapy, II Photodynamic therapy of PCN-224-Pt by intratumoral injection in a subcutaneous tumor model. A) HIF-1α staining of tumor tissues collected from mice in different groups. B) Photographs of the H22 tumor-bearing mice before treatment and on day 14 after the various treatments. C) Representative photographs of the tumor dissection. D) Relative tumor volume after various treatments indicated. Asterisks indicate significant differences (*P < 0.05, **P < 0.01, ***P < 0.001)