Fig. 7

Functionally grouped network of enriched biological pathways: The proteins networks were generated with high confidence interaction (overall 0.90 scores) in Cytoscape platform together in combination with Reactome database. Using the kappa score based statistics model, it provides the degree of relationship among the pathways associated with significant relevant overlapping proteins and Gene Ontology (GO) terms. The threshold 0.4 Kappa statistics was set, and above that, all the terms connections were selected to illustrate the significant interactome. The analysis uses the following parameters minimum three and maximum eight-level for GO tree, minimum 3% of genes of GO term/pathway, Benjamini and Hochberg test with the two-sided hypergeometric distribution of corrected FDR level < 0.05 significance. The protein–protein interaction maps represents the Akt/mTOR pathway, Map/Erk pathway, DNA damage responsive pathway and Ca²⁺ signaling cascade and endolysosomal machinery that include ubiquitination and proteasomal degradation