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Table 1 The coded and actual values of the variables used in central composite design

From: pH-responsive delivery vehicle based on RGD-modified polydopamine-paclitaxel-loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for targeted therapy in hepatocellular carcinoma

Symbol

Independent variables

Levels

− α

− 1

0

1

 + α

A

Water–oil ratio (v/v)

3:1

5:1

7:1

9:1

11:1

B

Polymer content (%)

2

2.5

3

3.5

4

C

PVA content (%)

0.05

0.1

0.15

0.2

0.25

D

Homogenization time (min)

3

5

7

9

11

Constraints

Dependent variables (Units)

     

Minimize

Y = particle size (nm)

     
  1. PVA polyvinyl alcohol