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Table 1 The coded and actual values of the variables used in central composite design

From: pH-responsive delivery vehicle based on RGD-modified polydopamine-paclitaxel-loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for targeted therapy in hepatocellular carcinoma

Symbol Independent variables Levels
− α − 1 0 1  + α
A Water–oil ratio (v/v) 3:1 5:1 7:1 9:1 11:1
B Polymer content (%) 2 2.5 3 3.5 4
C PVA content (%) 0.05 0.1 0.15 0.2 0.25
D Homogenization time (min) 3 5 7 9 11
Constraints Dependent variables (Units)      
Minimize Y = particle size (nm)      
  1. PVA polyvinyl alcohol