Fig. 5

The biodistribution profile of P12 through i.t., i.p. and i.v. administration in healthy mice. Healthy mice were treated with P12-Cy5 (500 nM) for 4 h via three different administration routes: i.t. (a), i.v. (b) and i.p. (c), and the major organs/tissues were assessed by gold content (ng/g organ or tissue) using ICP-MS. The amount of gold in the lung (d), liver (e), spleen (f), LN (g) and blood (h) through different administration routes was analyzed. (i) The photograph of lung and liver for P12 accumulation (dark color) with different administration routes. N = 5 per group, ns: not significant, *p < 0.05, ** p < 0.01