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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p

Fig. 6

miR-133a-3p level increased in MIF-Exo. Heat map based on exosomal miRNAs sequence values (red represents high expression and blue represents low expression) between MIF-Exo and siMIF-Exo. Top 15 upregulated miRNAs (a) and top 15 downregulated miRNAs (bB) were shown in MIF-Exo group. c Volcano plot showed log2 (Fold change) on x-axis and -log10 (P value) on y-axis. Heat map based on exosomal miRNAs sequence values between MIF-Exo and MSC-Exo group. Top 15 upregulated miRNAs (d) and top 15 downregulated miRNAs (e) in MIF-Exo group are shown. f Volcano plot showed log2 (Fold change) on the x-axis and -log10 (P value) on the y-axis. g In these upregulated miRNAs, 15 miRNAs were overlapped. h miR-133a-3p levels in MIF-Exo, MSC-Exo and siMIF-Exo groups were measured by qRT-PCR. (n = 3 biological replicates, 3 technical replicates for each biological replicate). All data were mean ± SEM. **P < 0.01; ***P < 0.001; NS, not significant

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Journal of Nanobiotechnology

ISSN: 1477-3155

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