Fig. 7

a In vivo CT imaging of orthotopic tumour-bearing mice before and 12 h after intravenous injection of iohexol, PGNSs, mPEG-PGNSs and mPEG/HER-PGNSs (red circles represent the tumour site); b CT values of the orthotopic tumour-bearing mice at different time points; c in vivo PA imaging of orthotopic tumour-bearing mice before and 2, 8, 24 h after intravenous injection of saline, PGNSs, mPEG-PGNSs and mPEG/HER-PGNSs (green arrows represent the PA signal); d PA intensity of the orthotopic tumour-bearing mice at different time points; e in vivo PT imaging with a NIR laser at 0, 1, 3 and 5 min of orthotopic tumour-bearing mice 24 h after intravenous injection of saline, PGNSs, mPEG-PGNSs and mPEG/HER-PGNSs (red circles represent the tumour site); and f temperature changes of the orthotopic tumour-bearing mice during NIR irradiation at different points. (^*p < 0.05, ^**p < 0.01, ^***p < 0.001)