Fig. 3
The capability of PMnC to modulate hypoxia. a The O2 concentration changes of H2O2 solution upon the addition of PBS, H2O@P NPs, free PMnC or M@P NPs. b Determination DO content of 4T1 cell after incubating with different NPs. The initial value was taken to be 100%. c Immunofluorescence staining images of tumor slices stained by the hypoxia probe at 24 h post injection of saline or M@P NPs. The scale bars are 50 μm. d PA images of 4T1 tumor-bearing mice with injection of saline or M@P NPs recorded in the Oxy-Hemo mode at pre and 24 h. e The semi-quantitative analysis of corresponding sO2 average total (%) values in tumor regions of figure (d)