Fig. 1

Schematic of the liver structure and hepatic cells. The liver comprises lobules, representing hepatic functional units (panel A). Each lobule is intersected by a central vein (CV), from which hepatocyte cords radiate towards portal triads (PTs) containing three different structures: bile ducts (BD), a hepatic artery (HA) and a portal vein (PV). Hepatocyte cords are separated by sinusoids, which are blood vessels lined by specialized fenestrated endothelial cells (liver sinusoidal cells). Hepatic stellate cells (HSCs) are located in the space of Disse, and portal fibroblasts (PFs) are located in the portal triad areas. Ductal epithelial cells line the bile ducts. Reprinted with permission from [202].