Fig. 3
From: Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis
Treatment with HGC-TAC reduced glomerular proliferative lesions and tubulointerstitial infiltration and decreased glomerular immune complex deposition in MRL/lpr mice. a Hematoxylin, eosin, and Periodic Acid-Schiff staining of kidney sections from wild-type (WT), MRL/lpr mice treated with vehicle, or MRL/lpr mice treated with an equivalent dose of TAC or HGC-TAC. b Immunofluorescence staining of kidney sections for C3, C1q, fibrinogen, IgG, IgA, and IgM. Original magnification ×200, Bar = 50 μm. c Scanning and transmission electron microscopy in each group. Red arrows indicate podocyte foot process effacements. Asterisk indicates mesangial deposition. Original magnification ×2000, ×8000 and ×10,000, respectively; Bar = 5 μm. This experiment was performed with 3 mice per group