Fig. 6

Treatment with HGC-TAC did improve renal glomerular fibrosis in MRL/lpr mice. a Western blot analysis of α smooth muscle actin (SMA) protein levels from wild-type (WT), MRL/lpr mice treated with vehicle, or MRL/lpr mice treated with an equivalent dose of TAC or HGC-TAC. b Relative protein intensities are presented. The values for the WT vehicle-treated group are set to 1. (n = 6 mice/group). c Masson’s trichrome staining of kidney sections from each group, Bar = 25 μm. d The fibrotic assessment of Masson’s trichrome-stained glomeruli was quantified and expressed as a percentage of positive glomerular area. All values are presented as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001. ns not statistically significant