Fig. 7

Treatment with HGC-TAC improved renal apoptosis in MRL/lpr mice. a TUNEL staining of kidney sections from wild-type (WT), MRL/lpr mice treated with vehicle, or MRL/lpr mice treated with an equivalent dose of TAC or HGC-TAC. Bar = 25 μm. b TUNEL positive cells were counted in each group and expressed as a percentage of total cells. c Western blot analysis of bax, bcl-2, cleaved caspase-3, P-p53 (Ser15), p53, and cytochrome C protein levels from each group. d Relative protein intensities are presented. The values for the WT vehicle-treated group are set to 1. (n = 6 mice/group). All values are presented as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001. ns not statistically significant