Fig. 2

The combination of PLGA NPs and a high-fat diet causes a significantly higher extension of plaques in ApoE^−/− mice. a ORO stained images of aortic sinus tissues in ApoE^−/− and C57 mice. b H&E stained images of aortic lipid cores (yellow dashed line and plaque ruptures (green arrows) in ApoE^−/− and C57 mice. c Images of collagen in the plaque areas stained by Masson’s trichrome. d Quantitative data of the atherosclerotic plaque area in the aortic root sections. e The lipid assays from serum during atherosclerotic development (TC, TG, LDL, HDL). n = 5, mean ± SD, *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001