Fig. 4

Characterization of PM hydrogels. a The sol-gel transition of PM hydrogels with temperature rose from 4 to 37 °C. b SEM images of PM hydrogels exhibiting the porous morphology (scale bars = 500 nm). c Rheological characterization of PM hydrogels from 5 to 45 °C; the cross point of G′ (dark color) and G″ (light color) was defined as gelation temperature. d In vitro release profiles of GT/siFAM₁₀ from PM hydrogels in PBS at 37 °C. e Viability of HaCaT cells assessed by CCK-8 assay after treatment with released GT/siMMP-9₁₀ from PM hydrogels at Day-1, Day-7 and Day-14. *P< 0.05