Fig. 9

Characterization of HA-PDA@IQ/DOX HG mediated PTA using the 4T1 subcutaneous tumor-bearing mice model. a Infrared thermal images of mice at varied time points of treatment under different conditions using 808 nm laser irradiation. b Corresponding temperature change curves at the breast tumor sites of mice in different groups upon laser irradiation. c Tumor volume change curves, d the body-weight change, and e the survival curves of mice in the different groups. Data are expressed as mean ± S.D. (n = 4) (**P < 0.01, ***P < 0.001 by t-test). f H&E-stained images of the major organs in the different groups. Scale bar: 200 μm