Fig. 8
In vivo chemo-radiation combined therapy efficacy of different formulations in mice bearing SKOV-3 tumor grafts. When the volume of tumors reached about 50 mm3, mice were intravenously injected with MnO2-free Pt@mPDA/PDA-ZHer2 NPs, Pt@mPDA/MnO2/PDA NPs or Pt@mPDA/MnO2/PDA-ZHer2 NPs every 2 days. Mice in control group were intravenously injected with same volume of PBS. Mice received an X-Ray radiation at a dose of 6 Gy for 24 h post-injection every 4 days except for PBS group. Tumor sizes and body weights were recorded every day. On the 14th day after inoculation, all the tumor grafts were removed, weighed. a Schematic illustration of process of the chemo-radiation combined therapy; b SKOV-3 tumor growth curves of different groups after intravenously injection of the formulations; c The images of tumors isolated after treatment for 8 days; d Mean weights of the tumors isolated on day 14; e Body weight changes over the 8 days of the experiments