Fig. 6

Multimodal PET/CT/NIRF images of orthotopic colon cancer and pre-, intra- and postoperative NIRF images. Multimodal PET/CT and NIRF images of the left (a) and right (b) orthotopic colon cancer model. The blue arrows denote colon tumors in situ. c Multimodal PET/CT and NIRF images of orthotopic colon cancer model (blue arrows) with liver metastasis (red arrows). d The visual observation of tumors and HE staining of pathological sections (scale bar: 50 μm). f Immunohistochemistry assay of CD31 in orthotopic and subcutaneous colon cancer. g Representative NIRF images of tumor-bearing mice pre-, intra-, and postoperatively. The red arrows point to the tumor