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Table 1 The biodistribution at different pre-targeting time points (10, 20 and 30 h). Data are expressed as mean ± standard deviation (%ID/g, n = 4)

From: Extracellular vesicles-based pre-targeting strategy enables multi-modal imaging of orthotopic colon cancer and image-guided surgery

Tissue

68 Ga-EV-Cy7

10 h

20 h

30 h

Blood

3.36 ± 0.40

2.25 ± 0.11

1.89 ± 0.53

Brain

0.07 ± 0.01

0.08 ± 0.01

0.07 ± 0.04

Heart

0.62 ± 0.11

0.67 ± 0.07

0.53 ± 0.21

Lung

0.89 ± 0.15

0.63 ± 0.08

0.75 ± 0.36

Liver

1.16 ± 0.10

0.95 ± 0.13

0.66 ± 0.24

Spleen

0.66 ± 0.13

0.77 ± 0.07

0.56 ± 0.25

Kidney

1.60 ± 0.42

1.63 ± 0.24

1.37 ± 0.54

Stomach

0.36 ± 0.08

0.24 ± 0.09

0.44 ± 0.15

Small intestine

0.46 ± 0.09

0.45 ± 0.02

0.36 ± 0.03

Large intestine

0.92 ± 0.17

0.51 ± 0.04

0.48 ± 0.04

Bone

0.88 ± 0.22

1.07 ± 0.14

0.77 ± 0.25

Muscle

0.23 ± 0.04

0.20 ± 0.03

0.40 ± 0.04

Tumor

0.87 ± 0.24

1.37 ± 0.13

1.05 ± 0.10