Fig. 9

Antitumor and preliminary safety studies of DA-P-SS-T/PTX nanomicelles in resistant cancer xenografts. The representative tumor tissues (A) and tumor growth curves (B) after intravenous injection of Taxol and self-assembled nanomicelles (red arrows indicate the days of injection). (C) TIR and the corresponding average tumor weight (D) after various treatments. TIR was calculated using the following equation: TIR (%) = [1 − X/Y] × 100%, where X corresponds to the mean weight of the tumors in the experimental group and Y corresponds to the mean weight of the tumors in the control groups. Intracellular ATP levels (E), western blot assay of the levels of P-gp (F), and quantitative analysis of relative expression of P-gp (G) in tumor tissue after various treatments. Body weight (H) and H&E (I) staining of the organ section of A549/ADR xenograft-bearing nude mice treated with various formulations in vivo. (1) Western blot; (2) quantitative analysis of relative expression of P-gp. The data are presented as the mean ± standard deviation (n = 5); *P < 0.05, **P < 0.01, ***P < 0.001 compared with the DA-P-SS-T/PTX nanomicelles