Fig. 7

HIV-1 inhibition of dendriplexes. Quantification of R5-HIV-1 infection in a PBMCs and b U87MG-CD4⁺CCR5⁺ cells treated with dendriplexes. Infection was measured by titration of supernatants on TZM.bl cell line. Infection was inferred from the measurement of luciferase activity 48 h post-titration and was represented as fold change of percentage from HIV-1 infection control. Dendriplexes were formed with non-labeled G2-SN15-PEG or G3-SN31-PEG cationic dendrimer and control or anti-HIV-1 microRNAs (hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-92a-3p, hsa-miR-133b and hsa-miR-149-5p). Data are represented as mean ± SD of three individual experiments performed in triplicate. DMR: dendrimer. (*p < 0.05; **p < 0.01; ***p < 0.001)