Fig. 3
From: Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies
Schematic illustrations of TME targeting. The TME is characterized by hypoxia, slight acidity, a high GSH level and so on. Taking advantage of these characteristics, GBNs can be modified to target the TME for better function. Abbreviations: TME, tumor microenvironment; GSH, glutathione; HIF, hypoxia-inducible factor; -S–S-, disulfide bond; CA IX, carbonic anhydrase; M75, a monoclonal antibody