Table 4 Application of GBNs in magnetothermal therapy
From: Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies
References | Type of GBN | Targeting ligands | Modification | Drugs | Properties | Cell line | Animal model | Results |
|---|---|---|---|---|---|---|---|---|
[187] | GO | _ | PEI, IONPs | DOX | Intratumorally injected | MCF-7 | BALB/c mice | Led to more apoptosis and demonstrated higher antitumor efficacy combined with AMF |
[188] | rGO | _ | SPIONs, PEG | _ | _ | MCF-7 | _ | Enhanced the magnetothermal ablation efficacy |
[189] | GO | HA | _ | DOX, PTX | Targeted delivery | MDA-MB-231, BT-474 | _ | MTT was used to enhance the efficacy of chemotherapeutics in killing tumor cells |
[190] | GO | _ | FVIOs | _ | Combined magnetothermal effect and ROS-related immunologic effect | 4T1 | A mouse 4T1 cell subcutaneous breast tumor model | Eliminated the tumor at a low dose and short time under AMF exposure |