Fig. 6

Targeting effect of ICG/PTX@RGE-EV on glioma was identified in vivo. A Fluorescence intensity ratio of tumor and normal tissues of nude mice following different treatments at different time points. B The relative statistical fluorescence imaging of tumor tissues of nude mice. C Fluorescence intensity ratio of tumor sections from nude mice following different treatment. D PTX concentration distribution in the plasma of nude mice following different treatment. E PTX contents in the heart, liver, spleen, lung, kidney, brain and tumor a 24 h after administration of nude mice determined with HPLC. Measurement data were expressed as mean ± standard deviation. Data comparison was analyzed by one-way ANOVA among multiple groups, followed by Tukey’s post hoc test. Data at different time points were compared by repeated measures ANOVA among multiple groups, followed by Tukey’s post hoc test. *p < 0.05. The experiment was repeated three times independently