Fig. 7

ICG/PTX@RGE-EV exerts inhibitory effect on glioma growth in vivo. A Tumor volume. B Tumor tissues identified by HE staining. C Nude mouse weight. D Survival period and median survival of nude mice (n = 10 mice/each group). Measurement data were expressed as mean ± standard deviation. Data comparison was analyzed by one-way ANOVA among multiple groups, followed by Tukey’s post hoc test. Data at different time points were compared by repeated measures ANOVA among multiple groups, followed by Tukey’s post hoc test. Survival rate of nude mice was calculated by the Kaplan–Meier plot. *p < 0.05. The experiment was repeated three times independently. ICG/PTX@RGE-EV + NIR: targeting combined therapy, PTX@RGE-EV: chemotherapy; ICG@RGE-EV + NIR: hyperthermia; ICG/PTX@EV + NIR: non-targeted chemotherapy-hyperthermia