Fig. 4

Sedative effects CrCi-CDs. A Effects on latency to loss of righting reflex. B Total sleep time. Inset, *p < 0.05 and **< 0.01, values are means, n = 10. Interval between administrations of pentobarbital until loss of righting reflex was recorded as onset of sleep. Time from loss to regaining of righting reflex was recorded as duration of sleep. C Rectal temperature change of mice treated with CrCi-CDs values are means, n = 10. D Rectal temperatures of different groups measured hourly from treatment initiation. Change (Δ) in rectal temperatures (ΔRT) of different groups measured 1, 2, 3, and 4 h after treatment; inset, *p < 0.05 and **p < 0.01