Fig. 11

Loss of lc3b led to more severe deteriorative pulmonary ultrapathological changes induced by CuONPs. Wild type and lc3b^-/- mice were intratracheally instilled of vehicle or 5 mg/kg CuONPs, respectively, then the lung tissues of indicated groups were collected 3 days after treatment. The ultrastructural pathology of lung tissues were determined by TEM. Scale bar, 2 μm. Note that the white stars indicate macrophage cells; the white arrows indicate mitochondria; the white triangles indicate lamellar corpuscle, which were the marker of type II alveolar epithelial cells; the black triangles indicate the dilatation and vesiculation of endoplasmic reticulum