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Table 1 The solubility of pure CA and its mechanical processed products

From: Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility and enhanced oral bioavailability

Sample

Ball-milling time (h)

Solubility (μg/mL)

Increase solubility (times)

CA

–

1.68 ± 0.66

–

BM-0.5 h

0.5

38.39 ± 8.86

 ~ 23

BM-1.0 h

1

50.97 ± 27.89

 ~ 30

BM-1.5 h

1.5

56.21 ± 16.89

 ~ 33

BM-2.0 h

2

63.78 ± 11.53

 ~ 38

BM-2.5 h

2.5

82.40 ± 25.32

 ~ 50

BM-3.0 h

3

65.23 ± 17.16

 ~ 39