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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway

Fig. 8

Melatonin alleviates Ti-particles induced osteolysis through the enrichment of gut microbiota metabolite butyrate. Melatonin reverses the dysbacteriosis triggered by inflammatory osteolysis and raises the relative abundance of SCFA producing bacterium. Enrichment of butyrate following the change of microbiota activates GPR109A and suppresses osteolysis via inhibiting NLRP3 inflammasome activation

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Journal of Nanobiotechnology

ISSN: 1477-3155

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