Calycosin-loaded nanoliposomes as potential nanoplatforms for treatment of diabetic nephropathy through regulation of mitochondrial respiratory function

Table 2 Main pharmacokinetic parameters of free calycosin and calycosin-loaded nanoliposome group after oral administration (mean ± SD, n = 3)

Parameters	Unit	Free calycosin group	Calycosin-loaded nanoliposome group
AUC_0−t	μg/L*h	409.11 ± 67.29	927.39 ± 124.91**
AUC_0−∞	μg/L*h	421.09 ± 73.27	945.37 ± 158.91**
MRT_0−t	h	8.68 ± 1.27	13.39 ± 1.93*
t _1/2	h	6.98 ± 0.96	9.29 ± 0.88*
T _max	h	0.19 ± 0.017	0.14 ± 0.019*
C _max	μg/L*h	298.27 ± 35.81	331.52 ± 47.08

*P < 0.05, **P < 0.01 vs free calycosin group
AUC Area under the time-concentration curve, t_1/2 Elimination half-life, MRT Mean residence time, T_max The time of peak concentration, C_max Peak concentration

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