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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy

Fig. 6

Effects of PLGA nanoparticle-encapsulated PF-562271 (PLGA-FAKi) treatment on the tumor microenvironment. a, b SPECT/CT images (a) and quantified tumor uptake (b) of 99mTc-labeled human serum albumin in B16-OVA tumor-bearing C57BL/6 mice after treatment with PLGA (n = 3) or PLGA-FAKi (n = 4). Tumors are indicated by dashed circles. c–e Immunofluorescence staining (c) and quantified fluorescence intensity (d) of fibroblast activation protein (FAP), and Sirius red staining (e) in B16-OVA tumors harvested from C57BL/6 mice after treatment with PLGA or PLGA-FAKi (n = 7/group). Data are presented as mean ± SD. *, P < 0.05; **, P < 0.01

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Journal of Nanobiotechnology

ISSN: 1477-3155

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