Fig. 4

Biocompatibility and biodistribution of PLGA@M in vivo. A Blood biochemistry analysis of the healthy BALB/c mice at 21 days after intravenous injected with PLGA@M (n = 3). B The serum levels of IL-6, IL-1β and TNF-α in the healthy BALB/c mice after 21 days of PLGA@M treatment (n = 3). C The distribution of PLGA-ICG@M in healthy mice by living fluorescence imaging (H: heart, Li: liver, S: Spleen, Lu: lung, K: kidney). D Histological images of heart, liver, spleen, lung, and kidney samples from sacrificed mice at 21 days with or without PLGA@M treatment. (Scale bar: 50 μm.)