Fig. 5

Targeted and therapeutic efficiency of PLGA@M in vivo. A Representative histological images of main organs derived from coronavirus infectious mouse model. (Scale bar: 50 μm. Black arrows represent inflammatory injury.) B Ex vivo fluorescence bio-imaging analysis of ICG fluorescent signal in livers and lungs of coronavirus infected mouse. C Survival curve of severe coronavirus infectious mice after treated with PLGA-LPV NPs, PLGA-LPV@M (n = 8). D The weight variations of coronavirus infectious mice after treated with PLGA-LPV NPs and PLGA-LPV@M (n = 8). Data presented as mean ± s.d. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001