Fig. 6

The efficacy of anti-inflammatory and antiviral by PLGA-LPV@M in vivo. The mRNA level of proinflammatory cytokines in the lung (A) and liver (B) tissues of coronavirus infectious mice with different treatment as measured by quantitative RT-PCR (n = 3). C The viral loads of lung and liver in coronavirus infectious mice after treated with PLGA-LPV NPs and PLGA-LPV@M (n = 3). D Histological and radiography analysis of lung derived from coronavirus infectious mice with different treatments. (Scale bar: 50 μm.) Data presented as mean ± s.d. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. ns not significant